Stadium: Baha Mar Convention Center
Home Manager: Herb Sendek Away Manager: Tony Stubblefield
| NCAAB | 2022/11/15 00:00 | DePaul v Minnesota | W | 69-53 |
| NCAAB | 2022/11/12 03:00 | Western Illinois v DePaul | W | 74-86 |
| NCAAB | 2022/11/08 00:45 | Loyola Maryland v DePaul | W | 66-72 |
| NCAAB | 2022/03/10 00:00 | DePaul v St Johns | L | 73-92 |
| NCAAB | 2022/03/05 22:00 | DePaul v Connecticut | L | 68-75 |
| NCAAB | 2022/03/03 02:00 | Marquette v DePaul | W | 80-91 |
| NCAAB | 2022/02/27 22:00 | St Johns v DePaul | W | 94-99 |
| NCAAB | 2022/02/25 01:00 | DePaul v Georgetown | W | 68-65 |
| NCAAB | 2022/11/15 02:00 | Santa Clara v Utah State | L | 74-96 |
| NCAAB | 2022/11/11 03:00 | Georgia Southern v Santa Clara | W | 62-78 |
| NCAAB | 2022/11/08 03:00 | Eastern Washington v Santa Clara | W | 72-84 |
| NIT | 2022/03/16 03:00 | Santa Clara v Washington State | L | 50-63 |
| NCAAB | 2022/03/08 04:30 | Santa Clara v Saint Mary's CA | L | 72-75 |
| NCAAB | 2022/03/06 05:30 | Portland v Santa Clara | W | 67-91 |
| NCAAB | 2022/02/26 22:00 | Portland v Santa Clara | W | 89-102 |
| NCAAB | 2022/02/25 03:00 | Santa Clara v Pepperdine | W | 89-73 |