Stadium: Orleans Arena
Home Manager: Herb Sendek Away Manager: Rick Pitino
| NCAAB | 2022/11/19 00:30 | Iona v Vermont | W | 71-50 |
| NCAAB | 2022/11/12 00:00 | Iona v Hofstra | L | 78-83 |
| NCAAB | 2022/11/08 00:00 | Pennsylvania v Iona | W | 50-78 |
| NIT | 2022/03/17 01:00 | Iona v Florida Gators | L | 74-79 |
| NCAAB | 2022/03/10 00:00 | Rider v Iona | L | 71-70 |
| NCAAB | 2022/03/05 18:00 | Quinnipiac v Iona | W | 61-79 |
| NCAAB | 2022/03/04 00:00 | Iona v Manhattan | L | 72-74 |
| NCAAB | 2022/02/27 19:00 | Iona v Rider | W | 67-61 |
| NCAAB | 2022/11/24 00:00 | Santa Clara v Menlo | W | 64-51 |
| NCAAB | 2022/11/21 00:00 | Central Florida v Santa Clara | L | 57-50 |
| NCAAB | 2022/11/19 02:30 | DePaul v Santa Clara | W | 61-69 |
| NCAAB | 2022/11/15 02:00 | Santa Clara v Utah State | L | 74-96 |
| NCAAB | 2022/11/11 03:00 | Georgia Southern v Santa Clara | W | 62-78 |
| NCAAB | 2022/11/08 03:00 | Eastern Washington v Santa Clara | W | 72-84 |
| NIT | 2022/03/16 03:00 | Santa Clara v Washington State | L | 50-63 |
| NCAAB | 2022/03/08 04:30 | Santa Clara v Saint Mary's CA | L | 72-75 |