Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Dave Dickerson
| NCAAB | 2022/11/11 23:30 | USC Upstate v Duke | L | 38-84 |
| NCAAB | 2022/11/08 00:30 | Brevard v USC Upstate | W | 42-90 |
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/11/12 00:00 | Clemson v SC Gamecocks | L | 58-60 |
| NCAAB | 2022/11/08 00:00 | The Citadel v Clemson | W | 69-80 |
| NCAAB | 2022/03/10 00:00 | Clemson v Virginia Tech | L | 75-76 |
| NCAAB | 2022/03/08 21:30 | NC State v Clemson | W | 64-70 |
| NCAAB | 2022/03/05 19:00 | Virginia Tech v Clemson | W | 59-63 |
| NCAAB | 2022/03/03 00:00 | Georgia Tech v Clemson | W | 65-68 |
| NCAAB | 2022/02/26 20:00 | Clemson v Boston College | W | 70-60 |
| NCAAB | 2022/02/24 00:00 | Wake Forest v Clemson | W | 69-80 |