Stadium: WVU Coliseum
Home Manager: Bob Huggins Away Manager: Steve Donahue
| NCAAB | 2022/11/16 00:00 | Pennsylvania v Drexel | W | 64-59 |
| NCAAB | 2022/11/13 21:00 | Towson v Pennsylvania | L | 80-74 |
| NCAAB | 2022/11/12 01:00 | Pennsylvania v Missouri | L | 85-92 |
| NCAAB | 2022/11/08 00:00 | Pennsylvania v Iona | L | 50-78 |
| NCAAB | 2022/03/12 19:00 | Pennsylvania v Yale | L | 61-67 |
| NCAAB | 2022/03/05 23:00 | Princeton v Pennsylvania | L | 93-70 |
| NCAAB | 2022/02/26 19:00 | Pennsylvania v Dartmouth | L | 70-84 |
| NCAAB | 2022/02/19 23:00 | Pennsylvania v Brown | W | 89-88 |
| NCAAB | 2022/11/16 00:00 | Morehead State v West Virginia | W | 57-75 |
| NCAAB | 2022/11/12 00:00 | West Virginia v Pittsburgh | W | 81-56 |
| NCAAB | 2022/11/08 00:00 | Mount St Marys v West Virginia | W | 58-76 |
| NCAAB | 2022/03/10 20:00 | West Virginia v Kansas | L | 63-87 |
| NCAAB | 2022/03/10 00:00 | West Virginia v Kansas State | W | 73-67 |
| NCAAB | 2022/03/05 19:00 | TCU v West Virginia | W | 64-70 |
| NCAAB | 2022/03/02 00:00 | West Virginia v Oklahoma | L | 59-72 |
| NCAAB | 2022/02/26 19:00 | Texas v West Virginia | L | 82-81 |