Stadium: Jack Breslin Students Events Center
Home Manager: Tom Izzo Away Manager: Kyle Neptune
| NCAAB | 2022/11/14 23:30 | Delaware State v Villanova | W | 50-60 |
| NCAAB | 2022/11/12 00:00 | Villanova v Temple | L | 64-68 |
| NCAAB | 2022/11/07 23:30 | La Salle v Villanova | W | 68-81 |
| NCAAB | 2022/04/02 22:09 | Villanova v Kansas | L | 65-81 |
| NCAAB | 2022/03/26 22:09 | Houston v Villanova | W | 44-50 |
| NCAAB | 2022/03/24 23:29 | Michigan v Villanova | W | 55-63 |
| NCAAB | 2022/03/20 18:40 | Ohio State v Villanova | W | 61-71 |
| NCAAB | 2022/03/18 18:45 | Delaware v Villanova | W | 60-80 |
| NCAAB | 2022/11/16 00:00 | Michigan State v Kentucky | W | 86-77 |
| NCAAB | 2022/11/11 23:30 | Michigan State v Gonzaga | L | 63-64 |
| NCAAB | 2022/11/08 00:00 | Northern Arizona v Michigan State | W | 55-73 |
| NCAAB | 2022/03/20 21:15 | Michigan State v Duke | L | 76-85 |
| NCAAB | 2022/03/19 01:40 | Davidson v Michigan State | W | 73-74 |
| NCAAB | 2022/03/12 20:30 | Michigan State v Purdue | L | 70-75 |
| NCAAB | 2022/03/11 23:30 | Michigan State v Wisconsin | W | 69-63 |
| NCAAB | 2022/03/10 23:30 | Maryland v Michigan State | W | 72-76 |