Stadium: Littlejohn Coliseum
Home Manager: Brad Brownell Away Manager: Tavaras Hardy
| NCAAB | 2022/11/18 00:00 | Washington University v Loyola Maryland | W | 53-81 |
| NCAAB | 2022/11/13 22:00 | Brown v Loyola Maryland | W | 70-75 |
| NCAAB | 2022/11/11 00:00 | Loyola Maryland v Penn State | L | 65-90 |
| NCAAB | 2022/11/08 00:45 | Loyola Maryland v DePaul | L | 66-72 |
| NCAAB | 2022/03/04 00:00 | Loyola Maryland v Boston U | L | 64-76 |
| NCAAB | 2022/02/26 19:00 | Loyola Maryland v American | L | 55-65 |
| NCAAB | 2022/02/24 00:00 | Loyola Maryland v Navy | L | 50-52 |
| NCAAB | 2022/02/20 22:00 | Lehigh v Loyola Maryland | W | 42-69 |
| NCAAB | 2022/11/19 00:00 | Bellarmine v Clemson | W | 66-76 |
| NCAAB | 2022/11/16 00:00 | USC Upstate v Clemson | W | 70-81 |
| NCAAB | 2022/11/12 00:00 | Clemson v SC Gamecocks | L | 58-60 |
| NCAAB | 2022/11/08 00:00 | The Citadel v Clemson | W | 69-80 |
| NCAAB | 2022/03/10 00:00 | Clemson v Virginia Tech | L | 75-76 |
| NCAAB | 2022/03/08 21:30 | NC State v Clemson | W | 64-70 |
| NCAAB | 2022/03/05 19:00 | Virginia Tech v Clemson | W | 59-63 |
| NCAAB | 2022/03/03 00:00 | Georgia Tech v Clemson | W | 65-68 |