Stadium: Lantz Arena
Home Manager: Marty Simmons Away Manager: Ryan Pedon
| NCAAB | 2022/11/08 01:00 | Western Illinois v Illinois St | L | 71-68 |
| NCAAB | 2022/03/04 18:00 | Illinois St v Northern Iowa | L | 65-78 |
| NCAAB | 2022/03/04 00:00 | Indiana State v Illinois St | W | 53-58 |
| NCAAB | 2022/02/26 21:00 | Indiana State v Illinois St | W | 66-86 |
| NCAAB | 2022/02/24 01:00 | Illinois St v Southern Illinois | L | 69-90 |
| NCAAB | 2022/02/22 01:00 | Loyola Chicago v Illinois St | L | 59-50 |
| NCAAB | 2022/02/19 19:00 | Illinois St v Bradley | L | 64-72 |
| NCAAB | 2022/02/16 01:00 | Northern Iowa v Illinois St | L | 72-70 |
| NCAAB | 2022/11/08 02:00 | Eastern Illinois v Illinois | L | 57-87 |
| NCAAB | 2022/02/26 21:30 | Austin Peay v Eastern Illinois | L | 64-52 |
| NCAAB | 2022/02/25 01:30 | Morehead State v Eastern Illinois | L | 82-46 |
| NCAAB | 2022/02/22 01:00 | Eastern Illinois v SIU Edwardsville | L | 52-66 |
| NCAAB | 2022/02/19 21:00 | Eastern Illinois v Tennessee State | L | 49-63 |
| NCAAB | 2022/02/18 01:00 | Eastern Illinois v Belmont | L | 57-81 |
| NCAAB | 2022/02/14 23:00 | Eastern Illinois v Austin Peay | L | 54-62 |
| NCAAB | 2022/02/12 21:30 | Tennessee Martin v Eastern Illinois | W | 70-82 |