Stadium: Minges Coliseum
Home Manager: Michael Schwartz Away Manager: Greg Gary
| NCAAB | 2022/03/05 23:00 | Mercer v Furman | L | 66-80 |
| NCAAB | 2022/03/05 00:30 | Western Carolina v Mercer | W | 53-81 |
| NCAAB | 2022/02/27 00:00 | Mercer v Wofford | L | 67-74 |
| NCAAB | 2022/02/24 00:00 | The Citadel v Mercer | L | 71-67 |
| NCAAB | 2022/02/19 19:00 | Mercer v Western Carolina | L | 65-69 |
| NCAAB | 2022/02/17 00:00 | East Tenn St v Mercer | W | 56-65 |
| NCAAB | 2022/02/13 20:00 | Mercer v NC Greensboro | W | 73-64 |
| NCAAB | 2022/02/11 00:00 | Mercer v VMI | L | 79-85 |
| NCAAB | 2022/03/10 18:00 | East Carolina v Cincinnati | L | 63-74 |
| NCAAB | 2022/03/05 20:00 | East Carolina v Wichita State | L | 62-70 |
| NCAAB | 2022/02/26 21:00 | Tulsa v East Carolina | W | 59-64 |
| NCAAB | 2022/02/24 00:00 | South Florida v East Carolina | W | 60-64 |
| NCAAB | 2022/02/20 19:00 | East Carolina v Central Florida | L | 66-69 |
| NCAAB | 2022/02/18 00:00 | East Carolina v South Florida | W | 65-57 |
| NCAAB | 2022/02/12 23:00 | SMU v East Carolina | L | 80-66 |
| NCAAB | 2022/02/09 01:00 | East Carolina v Tulsa | W | 73-71 |