Stadium: EagleBank Arena
Home Manager: Kim English Away Manager: Mike Brennan
| NCAAB | 2021/12/22 00:00 | American v George Mason | L | 44-67 |
| NCAAB | 2019/12/08 00:00 | American v George Mason | L | 53-68 |
| NCAAB | 2018/11/10 00:00 | American v George Mason | W | 78-75 |
| NCAAB | 2013/11/08 12:00 | George Mason v American | L | 63-60 |
| NCAAB | 2005/12/05 12:00 | George Mason v American | L | 75-35 |
| NCAAB | 2022/11/10 00:00 | American v Marist | L | 69-73 |
| NCAAB | 2022/03/04 00:00 | American v Navy | L | 64-71 |
| NCAAB | 2022/03/02 00:00 | American v Holy Cross | W | 69-63 |
| NCAAB | 2022/02/26 19:00 | Loyola Maryland v American | W | 55-65 |
| NCAAB | 2022/02/24 00:00 | American v Lehigh | L | 61-78 |
| NCAAB | 2022/02/21 23:30 | American v Colgate | L | 49-63 |
| NCAAB | 2022/02/19 19:00 | Army v American | W | 67-83 |
| NCAAB | 2022/02/17 00:00 | Navy v American | L | 55-46 |
| NCAAB | 2022/11/12 00:00 | Longwood v George Mason | W | 69-83 |
| NCAAB | 2022/11/08 01:00 | George Mason v Auburn | L | 52-70 |
| NCAAB | 2022/03/10 17:00 | George Mason v Fordham | L | 49-54 |
| NCAAB | 2022/03/05 21:00 | Massachusetts v George Mason | L | 83-80 |
| NCAAB | 2022/03/03 00:00 | George Mason v Davidson | L | 62-73 |
| NCAAB | 2022/02/27 19:30 | George Washington v George Mason | W | 62-69 |
| NCAAB | 2022/02/24 00:00 | George Mason v VA Commonwealth | L | 66-72 |
| NCAAB | 2022/02/20 19:30 | George Mason v Fordham | L | 47-50 |