Stadium: G.B. Hodge Center
Home Manager: Dave Dickerson Away Manager: Cliff Ellis
| NCAAB | 2022/11/12 00:00 | Coastal Carolina v Methodist Monarchs | W | 110-47 |
| NCAAB | 2022/11/08 00:00 | Coastal Carolina v St Mary's | W | 97-43 |
| NCAAB | 2022/04/01 22:00 | Fresno St v Coastal Carolina | L | 85-74 |
| NCAAB | 2022/03/29 00:00 | Coastal Carolina v South Alabama | W | 69-68 |
| NCAAB | 2022/03/21 23:00 | Florida Gulf Coast v Coastal Carolina | W | 68-84 |
| NCAAB | 2022/03/16 23:00 | Maryland Eastern-Shore v Coastal Carolina | W | 42-66 |
| NCAAB | 2022/03/04 01:30 | Georgia Southern v Coastal Carolina | L | 70-64 |
| NCAAB | 2022/02/26 00:30 | Coastal Carolina v Arkansas LR | W | 68-55 |
| NCAAB | 2022/11/16 00:00 | USC Upstate v Clemson | L | 70-81 |
| NCAAB | 2022/11/11 23:30 | USC Upstate v Duke | L | 38-84 |
| NCAAB | 2022/11/08 00:30 | Brevard v USC Upstate | W | 42-90 |
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |