Stadium: The Buc Dome
Home Manager: Barclay Radebaugh Away Manager: Reggie Theus
| NCAAB | 2022/11/17 01:00 | Bethune Cookman v Trinity Baptist | W | 83-46 |
| NCAAB | 2022/11/15 00:00 | Bethune Cookman v Florida National | W | 71-57 |
| NCAAB | 2022/11/11 01:30 | Bethune Cookman v Indiana | L | 49-101 |
| NCAAB | 2022/11/08 00:00 | Bethune Cookman v Iowa | L | 58-89 |
| NCAAB | 2022/03/05 21:00 | Bethune Cookman v Florida A&M | L | 73-84 |
| NCAAB | 2022/03/01 01:30 | Bethune Cookman v Grambling State | W | 69-63 |
| NCAAB | 2022/02/26 23:30 | Bethune Cookman v Southern | W | 87-84 |
| NCAAB | 2022/02/22 02:00 | Alabama State v Bethune Cookman | L | 89-78 |
| NCAAB | 2022/11/17 00:00 | Charleston Southern v Tulane | L | 79-99 |
| NCAAB | 2022/11/10 23:30 | Charleston Southern v Ohio State | L | 56-82 |
| NCAAB | 2022/11/08 01:00 | Toccoa Falls v Charleston Southern | W | 52-83 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | L | 62-72 |
| NCAAB | 2022/03/02 19:00 | Charleston Southern v UNC Asheville | W | 79-78 |
| NCAAB | 2022/02/26 21:00 | Charleston Southern v Winthrop | L | 86-92 |
| NCAAB | 2022/02/24 00:00 | Charleston Southern v Presbyterian | L | 48-68 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | L | 78-73 |