Stadium: Leavey Center
Home Manager: Herb Sendek Away Manager: Brian Burg
| NCAAB | 2022/11/09 03:00 | Georgia Southern v San Jose State | L | 48-63 |
| NCAAB | 2022/03/06 01:30 | Georgia Southern v Appalachian State | L | 60-73 |
| NCAAB | 2022/03/04 01:30 | Georgia Southern v Coastal Carolina | W | 70-64 |
| NCAAB | 2022/02/26 00:00 | UL Monroe v Georgia Southern | W | 75-81 |
| NCAAB | 2022/02/24 00:00 | UL Lafayette v Georgia Southern | L | 82-69 |
| NCAAB | 2022/02/19 20:00 | Georgia State v Georgia Southern | L | 58-49 |
| NCAAB | 2022/02/18 00:00 | Georgia Southern v Georgia State | L | 63-79 |
| NCAAB | 2022/02/12 19:00 | Georgia Southern v Coastal Carolina | L | 58-79 |
| NCAAB | 2022/11/08 03:00 | Eastern Washington v Santa Clara | W | 72-84 |
| NIT | 2022/03/16 03:00 | Santa Clara v Washington State | L | 50-63 |
| NCAAB | 2022/03/08 04:30 | Santa Clara v Saint Mary's CA | L | 72-75 |
| NCAAB | 2022/03/06 05:30 | Portland v Santa Clara | W | 67-91 |
| NCAAB | 2022/02/26 22:00 | Portland v Santa Clara | W | 89-102 |
| NCAAB | 2022/02/25 03:00 | Santa Clara v Pepperdine | W | 89-73 |
| NCAAB | 2022/02/20 02:00 | Santa Clara v Gonzaga | L | 69-81 |
| NCAAB | 2022/02/17 08:27 | Santa Clara v Loyola Marymount | W | 84-80 |