Home History
| Youth Tournament | 2022/11/09 19:00 | Everton U21 v PSG U21 | W | 2-1 |
| England Premier League 2 | 2022/11/06 13:00 | Arsenal U21 v Everton U21 | L | 3-1 |
| England Premier League 2 | 2022/10/29 11:00 | Everton U21 v Man City U21 | W | 6-3 |
| Youth Tournament | 2022/10/25 18:00 | Everton U21 v Hertha Berlin U21 | W | 4-1 |
| England Premier League 2 | 2022/10/22 13:00 | Liverpool U21 v Everton U21 | L | 2-1 |
| England EFL Trophy | 2022/10/18 18:00 | Hartlepool v Everton U21 | W | 0-6 |
| England Premier League 2 | 2022/10/09 13:00 | Crystal Palace U21 v Everton U21 | W | 3-4 |
| England EFL Trophy | 2022/10/04 18:00 | Harrogate Town v Everton U21 | D | 1-1 |
Away History
| England Premier League 2 | 2022/11/07 13:00 | Sunderland U21 v Southampton U21 | W | 1-3 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | W | 8-1 |
| England Premier League 2 | 2022/10/23 13:00 | Newcastle U21 v Southampton U21 | L | 3-2 |
| England EFL Trophy | 2022/10/18 18:45 | Newport County v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/10/08 11:00 | Southampton U21 v Aston Villa U21 | W | 2-0 |
| England EFL Trophy | 2022/10/04 18:00 | Exeter v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/09/16 18:00 | Leeds U21 v Southampton U21 | L | 6-2 |
| England EFL Trophy | 2022/08/30 18:00 | Forest Green v Southampton U21 | L | 3-1 |