Stadium: Gesling Stadium Round: 7
| NCAAF | 2022/11/12 19:00 | Case Western Reserve Spartans v Carnegie Mellon Tartans | W | 7-20 |
| NCAAF | 2022/10/29 17:00 | Carnegie Mellon Tartans v St Vincent Bearcats | W | 30-12 |
| NCAAF | 2022/10/22 23:00 | Carnegie Mellon Tartans v Geneva Golden Tornadoes | W | 41-0 |
| NCAAF | 2022/10/15 17:00 | Washington And Jefferson Presidents v Carnegie Mellon Tartans | W | 7-12 |
| NCAAF | 2022/10/08 17:00 | Waynesburg Yellow Jackets v Carnegie Mellon Tartans | W | 20-27 |
| NCAAF | 2022/10/01 23:00 | Carnegie Mellon Tartans v Westminster Titans | W | 10-0 |
| NCAAF | 2022/09/24 19:00 | Thiel Tomcats v Carnegie Mellon Tartans | W | 6-35 |
| NCAAF | 2022/09/17 17:00 | Carnegie Mellon Tartans v Grove City Wolverines | W | 40-33 |
| NCAAF | 2022/11/12 18:07 | Depauw Tigers v Wabash Little Giants | W | 49-14 |
| NCAAF | 2022/11/05 17:00 | Depauw Tigers v Oberlin Yeomen | W | 72-0 |
| NCAAF | 2022/10/29 17:00 | Kenyon Lords v Depauw Tigers | W | 35-58 |
| NCAAF | 2022/10/22 17:00 | Ohio Wesleyan Battling Bishops v Depauw Tigers | W | 21-22 |
| NCAAF | 2022/10/08 17:00 | Depauw Tigers v Wittenberg Tigers | L | 7-30 |
| NCAAF | 2022/10/01 23:00 | Denison Big Red v Depauw Tigers | W | 13-17 |
| NCAAF | 2022/09/24 17:00 | Depauw Tigers v Wooster Scots | W | 59-0 |
| NCAAF | 2022/09/17 16:00 | Hiram Terriers v Depauw Tigers | W | 0-44 |