Home History
| England U21 Premier League Cup | 2022/11/13 12:00 | Everton U21 v Southampton U21 | W | 1-2 |
| England Premier League 2 | 2022/11/07 13:00 | Sunderland U21 v Southampton U21 | W | 1-3 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | W | 8-1 |
| England Premier League 2 | 2022/10/23 13:00 | Newcastle U21 v Southampton U21 | L | 3-2 |
| England EFL Trophy | 2022/10/18 18:45 | Newport County v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/10/08 11:00 | Southampton U21 v Aston Villa U21 | W | 2-0 |
| England EFL Trophy | 2022/10/04 18:00 | Exeter v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/09/16 18:00 | Leeds U21 v Southampton U21 | L | 6-2 |
Away History
| England Development League 2 | 2022/11/14 14:00 | Birmingham U21 v Cardiff U21 | L | 0-2 |
| England Development League 2 | 2022/11/04 14:00 | Birmingham U21 v Sheff Utd U21 | D | 0-0 |
| England Development League 2 | 2022/10/31 13:00 | Crewe U21 v Birmingham U21 | W | 0-2 |
| England Development League 2 | 2022/10/24 13:00 | Birmingham U21 v Sheffield Wed U21 | W | 3-2 |
| England Development League 2 | 2022/10/17 12:30 | Birmingham U21 v Barnsley U21 | D | 1-1 |
| England U21 Premier League Cup | 2022/10/14 18:00 | Colchester U21 v Birmingham U21 | L | 2-1 |
| England Development League 2 | 2022/10/10 13:00 | Burnley U21 v Birmingham U21 | D | 2-2 |
| England Development League 2 | 2022/10/04 13:00 | Peterborough U21 v Birmingham U21 | L | 3-2 |