| Guatemala Reserve League | 2022/01/16 17:00 | Guastatoya Reserves v Deportivo Iztapa Reserves | L | 3-2 |
| Guatemala Reserve League | 2022/11/16 21:00 | CSD Comunicaciones Reserves v Deportivo Iztapa Reserves | L | 2-0 |
| Guatemala Reserve League | 2022/10/09 21:00 | Deportivo Iztapa Reserves v CSD Municipal Reserves | L | 0-1 |
| Guatemala Reserve League | 2022/08/31 14:00 | Malacateco Reserves v Deportivo Iztapa Reserves | L | 3-0 |
| Guatemala Reserve League | 2022/08/28 21:00 | Deportivo Iztapa Reserves v Antigua GFC Reserves | L | 0-3 |
| Guatemala Reserve League | 2022/08/10 21:15 | Deportivo Iztapa Reserves v Coban Imperial Reserves | L | 1-5 |
| Guatemala Reserve League | 2022/05/04 20:00 | Deportivo Iztapa Reserves v CD Achuapa Reserves | L | 2-3 |
| Guatemala Reserve League | 2022/04/30 21:00 | CSD Municipal Reserves v Deportivo Iztapa Reserves | W | 3-4 |
| Guatemala Reserve League | 2022/04/24 21:00 | Deportivo Iztapa Reserves v Antigua GFC Reserves | W | 5-2 |
| Guatemala Reserve League | 2022/11/16 15:00 | Guastatoya Reserves v CD Achuapa Reserves | W | 3-0 |
| Guatemala Reserve League | 2022/08/31 17:00 | Guastatoya Reserves v Coban Imperial Reserves | W | 2-1 |
| Guatemala Reserve League | 2022/08/10 17:00 | Guastatoya Reserves v Deportivo Mixco Reserves | W | 4-1 |
| Guatemala Reserve League | 2022/05/04 21:00 | Nueva Concepcion Reserves v Guastatoya Reserves | L | 2-1 |
| Guatemala Reserve League | 2022/04/20 17:00 | Guastatoya Reserves v CSD Comunicaciones Reserves | W | 2-0 |
| Guatemala Reserve League | 2022/04/09 18:00 | Antigua GFC Reserves v Guastatoya Reserves | W | 1-3 |
| Guatemala Reserve League | 2022/04/02 19:00 | Guastatoya Reserves v Santa Lucia FC Reserves | W | 2-1 |
| Guatemala Reserve League | 2022/03/27 21:00 | CD Achuapa Reserves v Guastatoya Reserves | W | 1-2 |