| Colombia Regional League | 2022/05/10 13:15 | Real Santuario v Envigado FC Reserves | L | 1-3 |
| Colombia Regional League | 2022/11/14 19:00 | Atletico Nacional Medellin Reserves v Real Santuario | L | 4-0 |
| Colombia Regional League | 2022/10/24 15:13 | Real Santuario v Atletico Nacional Medellin Reserves | W | 3-2 |
| Colombia Regional League | 2022/10/08 20:18 | Ferrovalvulas FC v Real Santuario | W | 1-3 |
| Colombia Regional League | 2022/08/15 15:13 | Real Santuario v Medellin City FC | W | 4-0 |
| Colombia Regional League | 2022/07/20 19:28 | Club Deportivo La Chalaca v Real Santuario | L | 4-2 |
| Colombia Regional League | 2022/07/09 17:20 | Real Santuario v Real San Jeronimo | W | 3-2 |
| Colombia Regional League | 2022/06/11 17:18 | Real Santuario v Total Soccer FC | W | 3-0 |
| Colombia Regional League | 2022/06/05 21:17 | Ferrovalvulas FC v Real Santuario | L | 2-0 |
| Colombia Regional League | 2022/11/15 17:00 | Envigado FC Reserves v CD Gallegol | D | 1-1 |
| Colombia Regional League | 2022/10/31 15:00 | Talento y Vida v Envigado FC Reserves | W | 0-1 |
| Colombia Regional League | 2022/10/18 13:00 | Medellin City FC v Envigado FC Reserves | L | 1-0 |
| Colombia Regional League | 2022/10/11 17:00 | Envigado FC Reserves v Molino Viejo | L | 0-2 |
| Colombia Regional League | 2022/10/04 16:43 | Total Soccer FC v Envigado FC Reserves | W | 1-3 |
| Colombia Regional League | 2022/07/27 13:13 | Envigado FC Reserves v Sellos Colombianos | W | 3-2 |
| Colombia Regional League | 2022/07/12 13:12 | Envigado FC Reserves v Ferrovalvulas FC | W | 1-0 |
| Colombia Regional League | 2022/06/10 13:00 | Envigado FC Reserves v Atletico Nacional Medellin Reserves | W | 2-0 |