Home History
| England Development League 2 | 2022/11/08 13:15 | Millwall U21 v Colchester U21 | L | 4-1 |
| England Development League 2 | 2022/11/01 13:30 | Watford U21 v Colchester U21 | W | 0-6 |
| England Development League 2 | 2022/10/25 13:00 | Cardiff U21 v Colchester U21 | L | 4-1 |
| England Development League 2 | 2022/10/18 18:00 | Colchester U21 v Reading U21 | D | 2-2 |
| England U21 Premier League Cup | 2022/10/14 18:00 | Colchester U21 v Birmingham U21 | W | 2-1 |
| England Development League 2 | 2022/10/11 12:00 | Colchester U21 v Bristol City U21 | L | 0-1 |
| England Development League 2 | 2022/10/03 14:00 | Swansea U21 v Colchester U21 | L | 4-1 |
| England Development League 2 | 2022/09/23 12:00 | QPR U21 v Colchester U21 | L | 2-0 |
Away History
| England U21 Premier League Cup | 2022/11/21 19:00 | Southampton U21 v Birmingham U21 | W | 4-0 |
| England U21 Premier League Cup | 2022/11/13 12:00 | Everton U21 v Southampton U21 | W | 1-2 |
| England Premier League 2 | 2022/11/07 13:00 | Sunderland U21 v Southampton U21 | W | 1-3 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | W | 8-1 |
| England Premier League 2 | 2022/10/23 13:00 | Newcastle U21 v Southampton U21 | L | 3-2 |
| England EFL Trophy | 2022/10/18 18:45 | Newport County v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/10/08 11:00 | Southampton U21 v Aston Villa U21 | W | 2-0 |
| England EFL Trophy | 2022/10/04 18:00 | Exeter v Southampton U21 | L | 2-1 |