Home History
| England League Cup Women | 2022/11/27 12:00 | London City Lionesses Women v Brighton & Hove Albion Women | L | 1-2 |
| England Championship Women | 2022/11/20 13:00 | Sheff Utd Women v London City Lionesses Women | W | 0-2 |
| England Championship Women | 2022/11/06 14:00 | London City Lionesses Women v Birmingham Women | W | 3-2 |
| England Championship Women | 2022/10/30 14:00 | London City Lionesses Women v Blackburn Women | D | 0-0 |
| England Championship Women | 2022/10/23 11:00 | Sunderland Women v London City Lionesses Women | W | 0-2 |
| England Championship Women | 2022/10/16 13:00 | Coventry Women v London City Lionesses Women | W | 0-5 |
| England League Cup Women | 2022/10/02 13:00 | London City Lionesses Women v West Ham Women | D | 2-2 |
| England Championship Women | 2022/09/25 11:00 | London City Lionesses Women v Durham Women | W | 3-0 |
Away History
| England Championship Women | 2022/11/20 14:00 | Blackburn Women v Southampton Women | D | 1-1 |
| England Championship Women | 2022/11/02 19:00 | Southampton Women v Coventry Women | W | 3-0 |
| England Championship Women | 2022/10/30 12:00 | Southampton Women v Sunderland Women | W | 1-0 |
| England Championship Women | 2022/10/23 13:00 | Sheff Utd Women v Southampton Women | W | 0-1 |
| England Championship Women | 2022/10/17 18:00 | Southampton Women v Birmingham Women | W | 1-0 |
| England League Cup Women | 2022/10/02 14:00 | Coventry Women v Southampton Women | L | 2-0 |
| England Championship Women | 2022/09/25 14:00 | Bristol City Women v Southampton Women | D | 1-1 |
| England Championship Women | 2022/09/18 11:30 | Crystal Palace Women v Southampton Women | W | 1-2 |