| Uruguay Reserve League | 2022/06/06 18:00 | Defensor Sporting Reserves v Deportivo Maldonado Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/11/28 13:00 | Albion FC Reserves v Deportivo Maldonado Reserves | W | 0-1 |
| Uruguay Reserve League | 2022/11/24 19:00 | Atletico Fenix Reserves v Deportivo Maldonado Reserves | L | 4-0 |
| Uruguay Reserve League | 2022/11/21 14:00 | Deportivo Maldonado Reserves v Cerro Largo Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/11/17 19:00 | Liverpool Montevideo Reserves v Deportivo Maldonado Reserves | L | 3-1 |
| Uruguay Reserve League | 2022/11/14 19:00 | Atletico River Plate Reserves v Deportivo Maldonado Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/11/08 13:00 | Deportivo Maldonado Reserves v Boston River Reserves | L | 1-2 |
| Uruguay Reserve League | 2022/11/03 19:00 | Plaza Colonia Reserves v Deportivo Maldonado Reserves | W | 1-2 |
| Uruguay Reserve League | 2022/10/25 16:00 | Deportivo Maldonado Reserves v Montevideo Wanderers Reserves | L | 1-2 |
| Uruguay Reserve League | 2022/12/01 19:00 | Defensor Sporting Reserves v Danubio Reserves | L | 0-5 |
| Uruguay Reserve League | 2022/11/24 19:00 | Cerrito Reserves v Defensor Sporting Reserves | W | 0-1 |
| Uruguay Reserve League | 2022/11/21 19:00 | Nacional de Montevideo Reserves v Defensor Sporting Reserves | L | 3-1 |
| Uruguay Reserve League | 2022/11/14 12:30 | Defensor Sporting Reserves v Albion FC Reserves | W | 5-1 |
| Uruguay Reserve League | 2022/11/04 13:00 | Atletico Fenix Reserves v Defensor Sporting Reserves | L | 5-0 |
| Uruguay Reserve League | 2022/10/25 18:00 | Defensor Sporting Reserves v Cerro Largo Reserves | W | 4-0 |
| Uruguay Reserve League | 2022/10/11 13:00 | Atletico River Plate Reserves v Defensor Sporting Reserves | D | 0-0 |
| Uruguay Reserve League | 2022/09/27 13:00 | Defensor Sporting Reserves v Boston River Reserves | L | 2-3 |