Head to Head
| Mexico Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | L | 3-0 |
| Mexico Liga MX | 2022/04/20 02:00 | Mazatlan FC v Santos Laguna | W | 1-0 |
| Club Friendly List | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | L | 1-0 |
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | L | 4-0 |
| Mexico Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlan FC | W | 2-4 |
| Mexico Liga MX | 2016/05/01 01:30 | Mazatlan FC v Santos Laguna | W | 3-2 |
Home History
| Club Friendly List | 2022/12/21 03:00 | Atlas v Mazatlan FC | L | 2-1 |
| Club Friendly List | 2022/12/17 03:00 | Chivas Guadalajara v Mazatlan FC | L | 1-0 |
| Club Friendly List | 2022/12/14 03:00 | Tigres UANL v Mazatlan FC | D | 0-0 |
| Mexico Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | L | 3-0 |
| Mexico Liga MX | 2022/09/24 00:00 | Necaxa v Mazatlan FC | D | 2-2 |
| Mexico Liga MX | 2022/09/17 02:00 | Mazatlan FC v Toluca | D | 1-1 |
| Mexico Liga MX | 2022/09/11 21:00 | Cruz Azul v Mazatlan FC | L | 2-0 |
| Mexico Liga MX | 2022/09/08 02:05 | Mazatlan FC v Atlas | W | 1-0 |
Away History
| Club Friendly List | 2022/12/20 03:00 | Chivas Guadalajara v Santos Laguna | L | 4-0 |
| Club Friendly List | 2022/12/13 03:00 | Atlas v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2022/10/17 00:06 | Santos Laguna v Toluca | L | 1-2 |
| Mexico Liga MX | 2022/10/14 00:06 | Toluca v Santos Laguna | L | 4-3 |
| Mexico Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | W | 3-0 |
| Mexico Liga MX | 2022/09/19 00:05 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexico Liga MX | 2022/09/15 02:05 | Club America v Santos Laguna | D | 3-3 |
| Mexico Liga MX | 2022/09/10 22:00 | Queretaro v Santos Laguna | D | 3-3 |