[15] OTT Senators 4-2 BUF Sabres [16] 2018-04-04 23:30
Stadium: KeyBank Center Round: 1
Home Manager: Phil Housley Away Manager: Guy Boucher
Head to Head
| NHL | 2018/03/09 00:30 | BUF Sabres v OTT Senators | L | 4-3 |
| NHL | 2018/02/16 00:30 | BUF Sabres v OTT Senators | W | 2-3 |
| NHL | 2017/12/13 00:00 | OTT Senators v BUF Sabres | L | 2-3 |
| NHL | 2017/02/15 00:30 | BUF Sabres v OTT Senators | L | 3-2 |
| NHL | 2017/02/05 00:00 | OTT Senators v BUF Sabres | L | 0-4 |
| NHL | 2016/11/30 00:30 | BUF Sabres v OTT Senators | L | 5-4 |
| NHL | 2016/11/10 00:30 | OTT Senators v BUF Sabres | W | 2-1 |
| NHL | 2016/11/05 23:00 | BUF Sabres v OTT Senators | L | 2-1 |
Home History
| NHL | 2018/04/02 23:30 | WIN Jets v OTT Senators | L | 6-5 |
| NHL | 2018/03/31 18:00 | OTT Senators v DET Red Wings | L | 0-2 |
| NHL | 2018/03/29 23:30 | FLA Panthers v OTT Senators | W | 2-3 |
| NHL | 2018/03/27 23:30 | NY Islanders v OTT Senators | L | 4-3 |
| NHL | 2018/03/26 23:00 | OTT Senators v CAR Hurricanes | L | 1-4 |
| NHL | 2018/03/24 23:00 | CAR Hurricanes v OTT Senators | L | 5-2 |
| NHL | 2018/03/22 23:30 | EDM Oilers v OTT Senators | L | 6-2 |
| NHL | 2018/03/20 23:30 | FLA Panthers v OTT Senators | L | 7-2 |
Away History
| NHL | 2018/04/02 23:00 | BUF Sabres v TOR Maple Leafs | L | 2-5 |
| NHL | 2018/04/01 00:00 | BUF Sabres v NAS Predators | W | 7-4 |
| NHL | 2018/03/29 23:00 | DET Red Wings v BUF Sabres | L | 6-3 |
| NHL | 2018/03/26 23:00 | BUF Sabres v TOR Maple Leafs | W | 3-2 |
| NHL | 2018/03/24 23:00 | BUF Sabres v NY Rangers | L | 1-5 |
| NHL | 2018/03/23 23:00 | MON Canadiens v BUF Sabres | L | 3-0 |
| NHL | 2018/03/21 23:00 | ARZ Coyotes v BUF Sabres | L | 4-1 |
| NHL | 2018/03/19 23:00 | NAS Predators v BUF Sabres | L | 4-0 |