| Colombia Regional League | 2022/08/15 15:13 | Real Santuario v Medellin City FC | L | 4-0 |
| Colombia Regional League | 2023/03/28 15:13 | Medellin City FC v Talento y Vida | W | 2-0 |
| Colombia Regional League | 2023/03/06 14:16 | Lula FC v Medellin City FC | L | 2-1 |
| Colombia Regional League | 2022/10/24 15:00 | Deportivo Alexis Garcia v Medellin City FC | W | 0-3 |
| Colombia Regional League | 2022/10/18 13:00 | Medellin City FC v Envigado FC Reserves | W | 1-0 |
| Colombia Regional League | 2022/10/04 17:00 | Medellin City FC v Politecnico J.I.C. | W | 3-0 |
| Colombia Regional League | 2022/09/21 15:00 | Molino Viejo v Medellin City FC | L | 3-0 |
| Colombia Regional League | 2022/09/07 17:00 | Sol de Oriente v Medellin City FC | L | 2-1 |
| Colombia Regional League | 2022/08/30 15:00 | Medellin City FC v FC Leones Reserves | W | 4-0 |
| Colombia Regional League | 2022/11/22 17:00 | Real Santuario v Envigado FC Reserves | L | 0-2 |
| Colombia Regional League | 2022/11/14 19:00 | Atletico Nacional Medellin Reserves v Real Santuario | L | 4-0 |
| Colombia Regional League | 2022/10/24 15:13 | Real Santuario v Atletico Nacional Medellin Reserves | W | 3-2 |
| Colombia Regional League | 2022/10/08 20:18 | Ferrovalvulas FC v Real Santuario | W | 1-3 |
| Colombia Regional League | 2022/08/15 15:13 | Real Santuario v Medellin City FC | W | 4-0 |
| Colombia Regional League | 2022/07/20 19:28 | Club Deportivo La Chalaca v Real Santuario | L | 4-2 |
| Colombia Regional League | 2022/07/09 17:20 | Real Santuario v Real San Jeronimo | W | 3-2 |
| Colombia Regional League | 2022/06/11 17:18 | Real Santuario v Total Soccer FC | W | 3-0 |