[6] Juan Martin Del Potro 1-6,6-7 John Isner [17] 2018-03-30 17:00
Stadium: Stadium Round: 28 Ground: Hardcourt outdoor
Head to Head
| ATP Paris | 2017/11/03 13:00 | Juan Martin Del Potro v John Isner | 4-6,7-6,4-6 |
| ATP Montreal | 2017/08/07 22:30 | Juan Martin Del Potro v John Isner | 7-5,7-5 |
| ATP Stockholm | 2016/10/19 16:30 | John Isner v Juan Martin Del Potro | 4-6,6-7 |
Home History
| ATP Miami | 2018/03/29 01:00 | Juan Martin Del Potro v Milos Raonic | 5-7,7-6,7-6 |
| ATP Miami | 2018/03/27 18:25 | Juan Martin Del Potro v Filip Krajinovic | 6-4,6-2 |
| ATP Miami | 2018/03/25 19:40 | Juan Martin Del Potro v Kei Nishikori | 6-2,6-2 |
| ATP Miami | 2018/03/24 00:00 | Juan Martin Del Potro v Robin Haase | 6-4,5-7,6-2 |
| ATP Indian Wells | 2018/03/18 20:00 | Roger Federer v Juan Martin Del Potro | 4-6,7-6,6-7 |
| ATP Indian Wells | 2018/03/17 20:40 | Milos Raonic v Juan Martin Del Potro | 2-6,3-6 |
| ATP Indian Wells | 2018/03/16 21:10 | Juan Martin Del Potro v Philipp Kohlschreiber | 3-6,6-3,6-4 |
| ATP Indian Wells | 2018/03/15 00:50 | Juan Martin Del Potro v Leonardo Mayer | 3-6,7-6,6-3 |
Away History
| ATP Miami | 2018/03/28 19:00 | Hyeon Chung v John Isner | 1-6,4-6 |
| ATP Miami | 2018/03/27 15:00 | John Isner v Marin Cilic | 7-6,6-3 |
| ATP Miami | 2018/03/25 21:25 | John Isner v Mikhail Youzhny | 6-4,6-3 |
| ATP Miami | 2018/03/23 21:50 | John Isner v Jiri Vesely | 7-6,1-6,6-3 |
| ATP Indian Wells | 2018/03/11 18:00 | John Isner v Gael Monfils | 7-6,6-7,5-7 |
| ATP Acapulco | 2018/02/27 01:00 | John Isner v Ryan Harrison | 3-6,6-7 |
| ATP Delray Beach | 2018/02/21 17:40 | Peter Gojowczyk v John Isner | 7-6,6-7,7-6 |
| ATP Delray Beach | 2018/02/20 16:00 | Radu Albot v John Isner | 7-5,3-6,4-6 |