Head to Head
| England U21 Premier League Cup | 2022/11/13 12:00 | Everton U21 v Southampton U21 | L | 1-2 |
Home History
| Premier League International Cup | 2023/11/28 19:00 | Everton U21 v Monaco U21 | W | 4-2 |
| Premier League International Cup | 2023/11/22 19:00 | Everton U21 v Athletic Bilbao U21 | W | 1-0 |
| England EFL Trophy | 2023/11/07 19:00 | Mansfield v Everton U21 | W | 0-1 |
| England Premier League 2 | 2023/11/04 12:00 | Man Utd U21 v Everton U21 | L | 3-1 |
| England Premier League 2 | 2023/10/29 13:00 | Newcastle U21 v Everton U21 | L | 1-0 |
| England Premier League 2 | 2023/09/29 18:00 | Everton U21 v Arsenal U21 | D | 1-1 |
| England EFL Trophy | 2023/09/26 18:00 | Burton Albion v Everton U21 | L | 2-0 |
| England Premier League 2 | 2023/09/22 18:00 | Everton U21 v Norwich U21 | W | 2-1 |
Away History
| Premier League International Cup | 2023/11/28 19:00 | Southampton U21 v Valencia U21 | L | 0-2 |
| England Premier League 2 | 2023/11/03 12:00 | Southampton U21 v Sunderland U21 | L | 1-2 |
| England Premier League 2 | 2023/10/30 19:00 | Wolverhampton U21 v Southampton U21 | L | 2-1 |
| Premier League International Cup | 2023/10/04 18:00 | Southampton U21 v Lyon U21 | L | 3-4 |
| England Premier League 2 | 2023/09/29 18:00 | Southampton U21 v Reading U21 | W | 6-0 |
| England Premier League 2 | 2023/09/22 18:00 | West Ham U21 v Southampton U21 | D | 3-3 |
| England Premier League 2 | 2023/09/01 14:00 | Fulham U21 v Southampton U21 | L | 5-1 |
| England Premier League 2 | 2023/08/25 17:00 | Southampton U21 v Liverpool U21 | L | 0-3 |