Stadium: Spratt Memorial Stadium Round: 1
| NCAAF | 2022/11/05 18:00 | Central Missouri Mules v Missouri Western Griffons | L | 40-37 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | W | 59-28 |
| NCAAF | 2019/09/22 00:00 | Missouri Western Griffons v Central Missouri Mules | L | 45-48 |
| NCAAF | 2018/09/15 18:00 | Central Missouri Mules v Missouri Western Griffons | L | 51-14 |
| NCAAF | 2022/11/12 19:00 | Missouri Western Griffons v Blue Tigers | W | 41-0 |
| NCAAF | 2022/11/05 18:00 | Central Missouri Mules v Missouri Western Griffons | L | 40-37 |
| NCAAF | 2022/10/29 18:00 | Missouri Western Griffons v Missouri Southern Lions | W | 31-27 |
| NCAAF | 2022/10/22 19:00 | Pittsburgh State Gorillas v Missouri Western Griffons | L | 28-16 |
| NCAAF | 2022/10/15 21:00 | Northeastern State Riverhawks v Missouri Western Griffons | W | 16-23 |
| NCAAF | 2022/10/08 21:00 | Missouri Western Griffons v Nebraska Kearney | L | 18-39 |
| NCAAF | 2022/10/01 18:30 | NW Missouri State v Missouri Western Griffons | L | 16-3 |
| NCAAF | 2022/09/24 23:00 | Missouri Western Griffons v Washburn Ichabods Football | L | 31-38 |
| NCAAF | 2022/11/12 20:00 | Central Oklahoma v Central Missouri Mules | L | 13-10 |
| NCAAF | 2022/11/05 18:00 | Central Missouri Mules v Missouri Western Griffons | W | 40-37 |
| NCAAF | 2022/10/29 18:00 | Central Missouri Mules v Blue Tigers | W | 61-14 |
| NCAAF | 2022/10/22 18:00 | Fort Hays State University Tigers v Central Missouri Mules | L | 27-14 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | W | 20-17 |
| NCAAF | 2022/10/08 18:00 | Emporia State v Central Missouri Mules | L | 44-27 |
| NCAAF | 2022/10/01 18:00 | Central Missouri Mules v Northeastern State Riverhawks | W | 35-13 |
| NCAAF | 2022/09/24 18:00 | Nebraska Kearney v Central Missouri Mules | L | 38-6 |