Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | L | 20-17 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 |
| NCAAF | 2019/10/05 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 42-71 |
| NCAAF | 2018/09/29 18:00 | Central Missouri Mules v Missouri Southern Lions | L | 61-7 |
| NCAAF | 2023/10/21 19:00 | Blue Tigers v Missouri Southern Lions | W | 5-63 |
| NCAAF | 2023/10/14 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 |
| NCAAF | 2023/10/07 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 22-35 |
| NCAAF | 2023/09/30 19:00 | Central Oklahoma v Missouri Southern Lions | L | 30-27 |
| NCAAF | 2023/09/23 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | W | 42-0 |
| NCAAF | 2023/09/16 17:00 | Nebraska Kearney v Missouri Southern Lions | W | 13-18 |
| NCAAF | 2023/09/07 23:00 | Washburn Ichabods Football v Missouri Southern Lions | W | 23-30 |
| NCAAF | 2023/09/01 00:00 | Missouri Southern Lions v NW Missouri State | L | 24-31 |
| NCAAF | 2023/10/21 18:30 | Central Missouri Mules v Emporia State | W | 77-27 |
| NCAAF | 2023/10/14 19:00 | Northeastern State Riverhawks v Central Missouri Mules | W | 24-63 |
| NCAAF | 2023/10/07 18:00 | Central Missouri Mules v Nebraska Kearney | W | 38-14 |
| NCAAF | 2023/09/30 18:00 | Central Missouri Mules v NW Missouri State | W | 41-38 |
| NCAAF | 2023/09/23 18:00 | Washburn Ichabods Football v Central Missouri Mules | W | 28-58 |
| NCAAF | 2023/09/16 18:00 | Central Missouri Mules v Pittsburgh State Gorillas | L | 37-38 |
| NCAAF | 2023/09/09 18:00 | Central Missouri Mules v Central Oklahoma | W | 41-17 |
| NCAAF | 2023/09/01 00:00 | Missouri Western Griffons v Central Missouri Mules | W | 38-45 |