Stadium: Soldier Field Round: 1
| NCAAF | 2022/11/19 19:00 | Prairie View v Mississippi Valley State | W | 7-27 |
| NCAAF | 2022/11/12 20:00 | Southern v Mississippi Valley State | L | 27-7 |
| NCAAF | 2022/11/03 23:30 | Alabama v Mississippi Valley State | W | 20-30 |
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | L | 45-35 |
| NCAAF | 2022/10/15 19:00 | Mississippi Valley State v Alabama State | L | 9-24 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | L | 30-7 |
| NCAAF | 2022/10/01 22:00 | Mississippi Valley State v Florida A&M | L | 7-34 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | L | 7-49 |
| NCAAF | 2022/11/05 17:00 | Central State v Kentucky Thorobreds | W | 31-30 |
| NCAAF | 2022/10/29 19:00 | Lane College Dragons v Central State | L | 42-31 |
| NCAAF | 2022/10/22 17:00 | Central State v Edward Waters Tigers | L | 13-45 |
| NCAAF | 2022/10/15 18:00 | Tuskegee v Central State | L | 49-34 |
| NCAAF | 2022/10/08 17:00 | Central State v Fort Valley State | L | 17-32 |
| NCAAF | 2022/10/01 22:00 | Allen Yellow Jackets v Central State | W | 32-35 |
| NCAAF | 2022/09/24 17:00 | Central State v Miles Golden Bears | L | 14-34 |
| NCAAF | 2022/09/17 16:00 | Bluefield State v Central State | L | 27-23 |