Stadium: William H. Greene Stadium Round: 1
| NCAAF | 2022/09/24 18:00 | William Jewell College Cardinals v Kentucky Wesleyan | W | 24-17 |
| NCAAF | 2021/09/25 16:00 | Kentucky Wesleyan v William Jewell College Cardinals | L | 41-21 |
| NCAAF | 2023/09/02 16:00 | William Jewell College Cardinals v Fort Lewis Skyhawks | W | 42-6 |
| NCAAF | 2022/11/12 19:00 | Quincy v William Jewell College Cardinals | W | 7-17 |
| NCAAF | 2022/11/05 18:00 | William Jewell College Cardinals v Indianapolis Greyhounds | L | 14-48 |
| NCAAF | 2022/10/29 18:00 | Lindenwood v William Jewell College Cardinals | L | 64-23 |
| NCAAF | 2022/10/22 18:00 | William Jewell College Cardinals v Truman Bulldogs | L | 7-42 |
| NCAAF | 2022/10/15 18:00 | William Jewell College Cardinals v Missouri S&t Miners | L | 14-41 |
| NCAAF | 2022/10/08 18:00 | Southwest Baptist University Bearcats v William Jewell College Cardinals | L | 44-21 |
| NCAAF | 2022/10/01 18:00 | William Jewell College Cardinals v McKendree | L | 34-45 |
| NCAAF | 2023/09/01 23:00 | West Florida v Kentucky Wesleyan | L | 35-3 |
| NCAAF | 2022/11/12 18:00 | Ashland Eagles v Kentucky Wesleyan | L | 41-10 |
| NCAAF | 2022/11/05 21:00 | Kentucky Wesleyan v Tiffin Dragons | L | 13-72 |
| NCAAF | 2022/10/29 16:00 | Walsh U. Cavaliers v Kentucky Wesleyan | L | 35-10 |
| NCAAF | 2022/10/22 17:00 | Ohio Dominican Panthers v Kentucky Wesleyan | L | 49-7 |
| NCAAF | 2022/10/15 21:00 | Kentucky Wesleyan v Findlay Oilers | L | 7-44 |
| NCAAF | 2022/10/08 18:00 | Quincy v Kentucky Wesleyan | L | 46-9 |
| NCAAF | 2022/10/01 23:00 | Kentucky Wesleyan v Hillsdale Chargers | W | 31-27 |