Stadium: Dwight T. Reed Stadium Round: 1
| NCAAF | 2022/10/08 19:00 | Missouri Southern Lions v Blue Tigers | L | 37-14 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | L | 32-52 |
| NCAAF | 2019/09/12 23:00 | Blue Tigers v Missouri Southern Lions | L | 14-38 |
| NCAAF | 2023/10/14 19:00 | Central Oklahoma v Blue Tigers | L | 59-17 |
| NCAAF | 2023/10/07 19:00 | Blue Tigers v Northeastern State Riverhawks | L | 13-28 |
| NCAAF | 2023/10/01 00:00 | Fort Hays State University Tigers v Blue Tigers | L | 71-3 |
| NCAAF | 2023/09/23 18:30 | NW Missouri State v Blue Tigers | L | 59-0 |
| NCAAF | 2023/09/16 23:00 | Blue Tigers v Washburn Ichabods Football | L | 10-24 |
| NCAAF | 2023/09/09 23:00 | Blue Tigers v Missouri Western Griffons | L | 14-68 |
| NCAAF | 2023/09/01 00:00 | Emporia State v Blue Tigers | L | 56-10 |
| NCAAF | 2022/11/12 19:00 | Missouri Western Griffons v Blue Tigers | L | 41-0 |
| NCAAF | 2023/10/14 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 |
| NCAAF | 2023/10/07 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | L | 22-35 |
| NCAAF | 2023/09/30 19:00 | Central Oklahoma v Missouri Southern Lions | L | 30-27 |
| NCAAF | 2023/09/23 19:00 | Missouri Southern Lions v Northeastern State Riverhawks | W | 42-0 |
| NCAAF | 2023/09/16 17:00 | Nebraska Kearney v Missouri Southern Lions | W | 13-18 |
| NCAAF | 2023/09/07 23:00 | Washburn Ichabods Football v Missouri Southern Lions | W | 23-30 |
| NCAAF | 2023/09/01 00:00 | Missouri Southern Lions v NW Missouri State | L | 24-31 |
| NCAAF | 2022/11/12 20:00 | Missouri Southern Lions v Washburn Ichabods Football | L | 20-37 |