Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2022/11/12 18:30 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-7 |
| NCAAF | 2022/11/05 19:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 38-22 |
| NCAAF | 2022/10/29 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 16-20 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | W | 13-28 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 9-10 |
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | L | 34-14 |
| NCAAF | 2022/09/30 19:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 10-42 |
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2021/11/13 16:00 | Union College Bulldogs v Rpi Engineers | L | 17-19 |
| NCAAF | 2021/10/30 17:00 | Union College Bulldogs v Hobart Statesmen | W | 27-20 |
| NCAAF | 2021/09/18 20:30 | Union College Bulldogs v Springfield Pride | W | 30-23 |
| NCAAF | 2021/09/11 16:00 | Worcester State Lancers v Union College Bulldogs | W | 13-62 |