Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2022/09/24 23:00 | Limestone Saints v Virginia Wise Highland Cavaliers | L | 27-13 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2019/11/02 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 6-27 |
| NCAAF | 2023/09/16 20:00 | Barton Bulldogs v Virginia Wise Highland Cavaliers | L | 28-24 |
| NCAAF | 2023/09/09 16:00 | Thomas More Saints v Virginia Wise Highland Cavaliers | L | 37-0 |
| NCAAF | 2023/09/02 23:00 | Virginia Wise Highland Cavaliers v Union College Bulldogs | W | 48-0 |
| NCAAF | 2022/11/12 18:30 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-7 |
| NCAAF | 2022/11/05 19:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 38-22 |
| NCAAF | 2022/10/29 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 16-20 |
| NCAAF | 2022/10/22 20:00 | Erskine Flying Fleet v Virginia Wise Highland Cavaliers | W | 13-28 |
| NCAAF | 2022/10/15 16:00 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 9-10 |
| NCAAF | 2023/09/16 16:00 | Limestone Saints v Carson–Newman Eagles | W | 45-14 |
| NCAAF | 2023/09/09 16:00 | Limestone Saints v West Alabama Tigers | L | 13-27 |
| NCAAF | 2023/08/31 23:00 | West Georgia v Limestone Saints | L | 21-19 |
| NCAAF | 2022/11/19 18:00 | West Florida v Limestone Saints | L | 45-19 |
| NCAAF | 2022/11/12 17:00 | Limestone Saints v Emory And Henry Wasps | W | 45-27 |
| NCAAF | 2022/11/05 16:00 | Limestone Saints v Barton Bulldogs | W | 34-28 |
| NCAAF | 2022/10/29 20:00 | Newberry Wolves v Limestone Saints | W | 37-42 |
| NCAAF | 2022/10/22 22:00 | Catawba College v Limestone Saints | W | 23-48 |