Stadium: James LaRosa Athletic Field Round: 1
| NCAAF | 2022/09/01 23:00 | Wheeling v Seton Hill Griffins | W | 25-11 |
| NCAAF | 2021/09/02 23:00 | Seton Hill Griffins v Wheeling | L | 16-14 |
| NCAAF | 2022/11/12 19:00 | Wheeling v Fairmont State | W | 31-28 |
| NCAAF | 2022/11/05 16:00 | Wheeling v University of Charleston Golden Eagles | L | 19-22 |
| NCAAF | 2022/10/29 16:00 | Concord University Mountain Lions v Wheeling | L | 62-31 |
| NCAAF | 2022/10/22 17:00 | West Liberty Hilltoppers v Wheeling | W | 21-42 |
| NCAAF | 2022/10/15 17:00 | Wheeling v Frostburg State | W | 31-27 |
| NCAAF | 2022/10/08 16:00 | Wheeling v Unc Pembroke Braves | L | 16-17 |
| NCAAF | 2022/10/01 16:00 | W. Virginia Bobcats v Wheeling | W | 0-37 |
| NCAAF | 2022/09/24 16:00 | Wheeling v Glenville State Pioneers | W | 34-23 |
| NCAAF | 2022/11/12 17:00 | Seton Hill Griffins v Millersville University of Pennsylvania Marauders | L | 10-14 |
| NCAAF | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst | W | 7-0 |
| NCAAF | 2022/10/29 16:00 | Edinboro v Seton Hill Griffins | W | 14-45 |
| NCAAF | 2022/10/22 18:00 | Iup Crimson Hawks v Seton Hill Griffins | L | 44-7 |
| NCAAF | 2022/10/15 22:00 | Seton Hill Griffins v California Vulcans | L | 14-21 |
| NCAAF | 2022/10/08 20:00 | Seton Hill Griffins v Clarion Golden Eagles | L | 13-40 |
| NCAAF | 2022/10/01 16:00 | Gannon University Golden Knights v Seton Hill Griffins | L | 21-10 |
| NCAAF | 2022/09/24 22:00 | Slippery Rock v Seton Hill Griffins | L | 30-2 |