Stadium: Chalmers Field and Miller Track Round: 1
| NCAAF | 2022/11/12 19:00 | Dubuque Spartans v Central Dutch | L | 21-24 |
| NCAAF | 2022/11/05 18:00 | Loras Duhawks v Dubuque Spartans | W | 20-27 |
| NCAAF | 2022/10/22 19:00 | Dubuque Spartans v Luther Norse | W | 68-7 |
| NCAAF | 2022/10/15 18:00 | Coe Kohawks v Dubuque Spartans | W | 14-15 |
| NCAAF | 2022/10/08 21:00 | Dubuque Spartans v Simpson Storm | W | 66-14 |
| NCAAF | 2022/10/01 18:00 | Buena Vista Beavers v Dubuque Spartans | W | 16-46 |
| NCAAF | 2022/09/24 18:00 | Dubuque Spartans v Wartburg Knights | L | 0-25 |
| NCAAF | 2022/09/17 18:00 | Nebraska Wesleyan Prairie Wolves v Dubuque Spartans | W | 34-48 |
| NCAAF | 2022/11/12 18:00 | Wittenberg Tigers v Hilbert Hawks | W | 56-8 |
| NCAAF | 2022/11/05 17:00 | Wittenberg Tigers v Ohio Wesleyan Battling Bishops | L | 7-14 |
| NCAAF | 2022/10/29 17:30 | Wooster Scots v Wittenberg Tigers | L | 44-43 |
| NCAAF | 2022/10/22 16:00 | Wittenberg Tigers v Denison Big Red | L | 10-28 |
| NCAAF | 2022/10/15 20:00 | Wittenberg Tigers v Oberlin Yeomen | W | 62-7 |
| NCAAF | 2022/10/08 17:00 | Depauw Tigers v Wittenberg Tigers | W | 7-30 |
| NCAAF | 2022/10/01 17:00 | Wittenberg Tigers v Wabash Little Giants | L | 35-42 |
| NCAAF | 2022/09/24 16:00 | Hiram Terriers v Wittenberg Tigers | W | 14-38 |