Stadium: Hempstead Stadium Round: 1
| NCAAF | 2022/09/03 16:00 | St Lawrence Saints v Endicott Gulls | W | 0-27 |
| NCAAF | 2021/09/04 16:00 | Endicott Gulls v St Lawrence Saints | W | 27-14 |
| NCAAF | 2022/11/19 17:00 | Endicott Gulls v Springfield Pride | L | 14-17 |
| NCAAF | 2022/11/12 18:00 | Western New England Golden Bears v Endicott Gulls | W | 21-26 |
| NCAAF | 2022/11/05 16:00 | Endicott Gulls v Salve Regina Seahawks | W | 42-10 |
| NCAAF | 2022/10/29 17:00 | Curry Colonels v Endicott Gulls | W | 7-48 |
| NCAAF | 2022/10/22 17:00 | University of New England Noreasters v Endicott Gulls | W | 0-43 |
| NCAAF | 2022/10/08 16:00 | Endicott Gulls v Nichols Bison | W | 52-7 |
| NCAAF | 2022/10/01 16:00 | Endicott Gulls v Husson Eagles | W | 20-0 |
| NCAAF | 2022/09/24 16:00 | Endicott Gulls v Norwich Cadets | W | 26-13 |
| NCAAF | 2022/11/12 18:00 | St Lawrence Saints v Buffalo State Bengals | W | 31-7 |
| NCAAF | 2022/11/05 16:00 | Rpi Engineers v St Lawrence Saints | L | 10-6 |
| NCAAF | 2022/10/29 16:00 | Rochester Yellowjackets v St Lawrence Saints | W | 31-35 |
| NCAAF | 2022/10/22 17:00 | St Lawrence Saints v Hobart Statesmen | L | 10-31 |
| NCAAF | 2022/10/15 17:00 | Ithaca Bombers v St Lawrence Saints | L | 40-0 |
| NCAAF | 2022/10/08 17:00 | St Lawrence Saints v Union Dutchmen | L | 7-44 |
| NCAAF | 2022/09/24 16:00 | Castleton Spartans v St Lawrence Saints | W | 6-34 |
| NCAAF | 2022/09/16 23:00 | St Lawrence Saints v Morrisville State Mustangs | L | 15-17 |