Stadium: Don Drumm Stadium Round: 1
| NCAAF | 2022/11/12 18:30 | Muskingum Muskies v Marietta Pioneers | W | 23-38 |
| NCAAF | 2022/11/05 17:30 | Marietta Pioneers v Capital Crusaders | W | 50-14 |
| NCAAF | 2022/10/29 17:30 | Marietta Pioneers v Ohio Northern Polar Bears | W | 27-10 |
| NCAAF | 2022/10/22 18:00 | Heidelberg Student Princes v Marietta Pioneers | L | 29-21 |
| NCAAF | 2022/10/15 17:30 | Marietta Pioneers v Wilmington Quakers | W | 34-0 |
| NCAAF | 2022/10/08 17:30 | John Carroll Blue Streaks v Marietta Pioneers | L | 45-10 |
| NCAAF | 2022/10/01 21:00 | Marietta Pioneers v Baldwin Wallace Yellow Jackets | L | 29-33 |
| NCAAF | 2022/09/24 18:00 | Otterbein Cardinals v Marietta Pioneers | W | 10-27 |
| NCAAF | 2022/11/12 18:00 | St John Fisher Cardinals v Utica Pioneers | L | 21-35 |
| NCAAF | 2022/11/05 17:00 | Cortland Red Dragons v St John Fisher Cardinals | L | 56-14 |
| NCAAF | 2022/10/29 18:00 | St John Fisher Cardinals v Hartwick Hawks | W | 44-26 |
| NCAAF | 2022/10/15 17:00 | Alfred Saxons v St John Fisher Cardinals | W | 7-21 |
| NCAAF | 2022/10/08 17:00 | St John Fisher Cardinals v Morrisville State Mustangs | L | 3-10 |
| NCAAF | 2022/10/01 22:00 | Brockport Golden Eagles v St John Fisher Cardinals | L | 25-0 |
| NCAAF | 2022/09/24 20:00 | St John Fisher Cardinals v Rpi Engineers | W | 3-0 |
| NCAAF | 2022/09/17 17:00 | Hobart Statesmen v St John Fisher Cardinals | L | 17-0 |