Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2022/11/12 18:30 | Bluffton Beavers v Defiance Yellow Jackets | W | 14-17 |
| NCAAF | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | W | 24-21 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 76-35 |
| NCAAF | 2022/10/22 17:30 | Defiance Yellow Jackets v Anderson Ravens | W | 32-22 |
| NCAAF | 2022/10/15 17:30 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 48-19 |
| NCAAF | 2022/10/08 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 55-35 |
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | L | 20-37 |
| NCAAF | 2022/09/24 16:00 | Alfred State Pioneers v Defiance Yellow Jackets | L | 42-33 |
| NCAAF | 2022/12/17 00:00 | Mount Union v North Central Illinois | L | 21-28 |
| NCAAF | 2022/12/10 17:00 | Mount Union v Wartburg Knights | W | 34-31 |
| NCAAF | 2022/12/03 17:00 | Mount Union v Delaware Valley Aggies | W | 22-6 |
| NCAAF | 2022/11/26 17:00 | Mount Union v Utica Pioneers | W | 45-7 |
| NCAAF | 2022/11/19 17:00 | Mount Union v Salisbury Sea Gulls | W | 51-0 |
| NCAAF | 2022/11/12 18:30 | Baldwin Wallace Yellow Jackets v Mount Union | W | 21-23 |
| NCAAF | 2022/11/05 17:30 | Mount Union v John Carroll Blue Streaks | W | 34-28 |
| NCAAF | 2022/10/29 18:00 | Otterbein Cardinals v Mount Union | W | 0-59 |