Stadium: England Stadium Round: 1
| NCAAF | 2022/11/12 18:00 | Illinois College Blueboys v Beloit Buccaneers | W | 65-13 |
| NCAAF | 2022/10/29 00:00 | Illinois College Blueboys v Cornell Rams | W | 28-14 |
| NCAAF | 2022/10/22 18:00 | Knox Prairie Fire v Illinois College Blueboys | W | 10-20 |
| NCAAF | 2022/10/15 18:00 | Illinois College Blueboys v Lawrence Vikings | W | 57-0 |
| NCAAF | 2022/10/08 19:00 | Lake Forest Foresters v Illinois College Blueboys | L | 40-7 |
| NCAAF | 2022/10/01 18:00 | Illinois College Blueboys v Ripon Red Hawks | L | 21-23 |
| NCAAF | 2022/09/17 18:00 | Monmouth Scots v Illinois College Blueboys | L | 51-20 |
| NCAAF | 2022/09/10 18:00 | Illinois College Blueboys v Chicago Maroons | L | 14-40 |
| NCAAF | 2022/11/12 19:00 | Carthage Red Men v Millikin Big Blue | W | 6-17 |
| NCAAF | 2022/11/05 18:00 | Millikin Big Blue v Carroll Pioneers | L | 18-26 |
| NCAAF | 2022/10/29 18:00 | Wheaton Thunder v Millikin Big Blue | L | 69-3 |
| NCAAF | 2022/10/22 18:00 | Millikin Big Blue v Elmhurst Bluejays | W | 13-0 |
| NCAAF | 2022/10/15 18:00 | North Central Illinois v Millikin Big Blue | L | 65-0 |
| NCAAF | 2022/10/08 18:00 | Millikin Big Blue v Augustana Augie | L | 0-70 |
| NCAAF | 2022/10/01 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | L | 38-24 |
| NCAAF | 2022/09/24 18:00 | Millikin Big Blue v North Park Vikings | W | 23-21 |