Stadium: Lewis C. Everett Stadium Round: 1
| NCAAF | 2022/11/12 18:00 | Hampden Sydney Tigers v Randolph Macon Yellow Jackets | L | 17-38 |
| NCAAF | 2022/11/05 17:00 | Shenandoah Hornets v Hampden Sydney Tigers | L | 23-7 |
| NCAAF | 2022/10/29 17:00 | Hampden Sydney Tigers v Guilford Quakers | W | 28-21 |
| NCAAF | 2022/10/22 17:00 | Washington And Lee Generals v Hampden Sydney Tigers | W | 43-44 |
| NCAAF | 2022/10/15 17:00 | Hampden Sydney Tigers v Averett Cougars | W | 37-26 |
| NCAAF | 2022/10/08 19:30 | Ferrum Panthers v Hampden Sydney Tigers | W | 16-35 |
| NCAAF | 2022/10/01 18:00 | Bridgewater Eagles v Hampden Sydney Tigers | L | 27-17 |
| NCAAF | 2022/09/17 17:00 | Hampden Sydney Tigers v Greensboro Pride | W | 70-28 |
| NCAAF | 2022/11/12 18:07 | Depauw Tigers v Wabash Little Giants | L | 49-14 |
| NCAAF | 2022/11/05 17:00 | Wabash Little Giants v Kenyon Lords | W | 49-25 |
| NCAAF | 2022/10/29 17:00 | Wabash Little Giants v Hiram Terriers | W | 59-23 |
| NCAAF | 2022/10/22 17:00 | Oberlin Yeomen v Wabash Little Giants | W | 20-66 |
| NCAAF | 2022/10/15 17:00 | Wabash Little Giants v Ohio Wesleyan Battling Bishops | W | 41-24 |
| NCAAF | 2022/10/01 17:00 | Wittenberg Tigers v Wabash Little Giants | W | 35-42 |
| NCAAF | 2022/09/24 18:00 | Wabash Little Giants v Denison Big Red | L | 42-45 |
| NCAAF | 2022/09/17 18:00 | Wooster Scots v Wabash Little Giants | W | 14-48 |