Stadium: Cook Stadium Round: 1
| NCAAF | 2022/09/03 17:00 | Depauw Tigers v Rose Hulman Engineers | L | 17-14 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | L | 26-21 |
| NCAAF | 2022/11/12 18:30 | Mount St. Joseph Lions v Rose Hulman Engineers | L | 40-31 |
| NCAAF | 2022/11/05 18:00 | Hanover v Rose Hulman Engineers | W | 17-47 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | W | 76-35 |
| NCAAF | 2022/10/22 17:30 | Rose Hulman Engineers v Franklin College Grizzlies | W | 49-0 |
| NCAAF | 2022/10/15 17:30 | Bluffton Beavers v Rose Hulman Engineers | W | 20-48 |
| NCAAF | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | W | 48-14 |
| NCAAF | 2022/10/01 17:30 | Anderson Ravens v Rose Hulman Engineers | W | 7-45 |
| NCAAF | 2022/09/17 16:00 | Rose Hulman Engineers v Albion Britons | L | 17-49 |
| NCAAF | 2022/11/19 17:00 | Carnegie Mellon Tartans v Depauw Tigers | L | 45-14 |
| NCAAF | 2022/11/12 18:07 | Depauw Tigers v Wabash Little Giants | W | 49-14 |
| NCAAF | 2022/11/05 17:00 | Depauw Tigers v Oberlin Yeomen | W | 72-0 |
| NCAAF | 2022/10/29 17:00 | Kenyon Lords v Depauw Tigers | W | 35-58 |
| NCAAF | 2022/10/22 17:00 | Ohio Wesleyan Battling Bishops v Depauw Tigers | W | 21-22 |
| NCAAF | 2022/10/08 17:00 | Depauw Tigers v Wittenberg Tigers | L | 7-30 |
| NCAAF | 2022/10/01 23:00 | Denison Big Red v Depauw Tigers | W | 13-17 |
| NCAAF | 2022/09/24 17:00 | Depauw Tigers v Wooster Scots | W | 59-0 |