Stadium: Schmidt Stadium Round: 1
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | W | 21-48 |
| NCAAF | 2021/09/04 17:00 | Wilkes Colonels v Keystone Giants | W | 46-7 |
| NCAAF | 2023/10/07 16:00 | Lycoming Warriors v Wilkes Colonels | W | 35-48 |
| NCAAF | 2023/09/30 16:00 | Wilkes Colonels v Juniata Eagles | W | 63-14 |
| NCAAF | 2023/09/23 20:00 | St John Fisher Cardinals v Wilkes Colonels | L | 29-20 |
| NCAAF | 2023/09/16 16:00 | Wilkes Colonels v Brockport Golden Eagles | L | 7-31 |
| NCAAF | 2023/09/09 16:00 | Rpi Engineers v Wilkes Colonels | L | 38-14 |
| NCAAF | 2023/09/02 16:00 | Wilkes Colonels v Kings Monarchs | L | 23-27 |
| NCAAF | 2022/11/12 17:00 | Wilkes Colonels v Kings Monarchs | W | 58-42 |
| NCAAF | 2022/11/05 16:00 | Stevenson Mustangs v Wilkes Colonels | L | 28-0 |
| NCAAF | 2023/10/07 17:00 | Keystone Giants v Susquehanna Crusaders | L | 0-69 |
| NCAAF | 2023/09/30 17:00 | Moravian Greyhounds v Keystone Giants | L | 58-34 |
| NCAAF | 2023/09/23 22:00 | Hobart Statesmen v Keystone Giants | L | 43-10 |
| NCAAF | 2023/09/16 17:00 | Keystone Giants v St John Fisher Cardinals | L | 20-35 |
| NCAAF | 2023/09/09 17:00 | Hartwick Hawks v Keystone Giants | L | 31-21 |
| NCAAF | 2023/09/02 16:00 | Keystone Giants v Gallaudet Bison | W | 27-6 |
| NCAAF | 2022/11/12 17:00 | Dean Bulldogs v Keystone Giants | W | 44-45 |
| NCAAF | 2022/11/05 17:00 | Keystone Giants v Suny Maritime Privateers | W | 21-20 |