Head to Head
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | L | 28-27 |
| NFL | 2014/09/07 17:00 | CHI Bears v BUF Bills | L | 20-23 |
Home History
| NFL | 2018/10/28 17:00 | NY Jets v CHI Bears | W | 10-24 |
| NFL | 2018/10/21 17:00 | NE Patriots v CHI Bears | L | 38-31 |
| NFL | 2018/10/14 17:00 | CHI Bears v MIA Dolphins | L | 28-31 |
| NFL | 2018/09/30 17:00 | TB Buccaneers v CHI Bears | W | 10-48 |
| NFL | 2018/09/23 20:25 | CHI Bears v ARZ Cardinals | W | 16-14 |
| NFL | 2018/09/18 00:15 | SEA Seahawks v CHI Bears | W | 17-24 |
| NFL | 2018/09/10 00:20 | CHI Bears v GB Packers | L | 23-24 |
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | L | 28-27 |
Away History
| NFL | 2018/10/30 00:15 | NE Patriots v BUF Bills | L | 25-6 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | L | 5-37 |
| NFL | 2018/10/14 17:00 | BUF Bills v HOU Texans | L | 13-20 |
| NFL | 2018/10/07 17:00 | TEN Titans v BUF Bills | W | 12-13 |
| NFL | 2018/09/30 17:00 | BUF Bills v GB Packers | L | 0-22 |
| NFL | 2018/09/23 17:00 | BUF Bills v MIN Vikings | W | 27-6 |
| NFL | 2018/09/16 17:00 | LA Chargers v BUF Bills | L | 31-20 |
| NFL | 2018/09/09 17:00 | BUF Bills v BAL Ravens | L | 3-47 |