Stadium: Carl W. Burt Memorial Stadium Round: 1
| NCAAF | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | L | 24-21 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |
| NCAAF | 2019/11/09 18:30 | Defiance Yellow Jackets v Manchester Spartans | W | 0-19 |
| NCAAF | 2019/09/19 23:00 | Manchester Spartans v Defiance Yellow Jackets | W | 52-21 |
| NCAAF | 2018/09/15 22:00 | Manchester Spartans v Defiance Yellow Jackets | W | 57-26 |
| NCAAF | 2023/10/21 17:30 | Bluffton Beavers v Manchester Spartans | L | 50-12 |
| NCAAF | 2023/10/14 17:30 | Hanover v Manchester Spartans | L | 34-0 |
| NCAAF | 2023/10/07 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 7-44 |
| NCAAF | 2023/09/30 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 69-14 |
| NCAAF | 2023/09/16 17:00 | Manchester Spartans v Greenville Panthers | L | 7-59 |
| NCAAF | 2023/09/09 20:00 | Manchester Spartans v Alma College Scots | L | 0-68 |
| NCAAF | 2023/09/02 22:00 | Manchester Spartans v North Park Vikings | L | 0-27 |
| NCAAF | 2022/11/12 18:30 | Anderson Ravens v Manchester Spartans | L | 19-12 |
| NCAAF | 2023/10/21 17:30 | Anderson Ravens v Defiance Yellow Jackets | W | 6-36 |
| NCAAF | 2023/10/14 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 21-35 |
| NCAAF | 2023/10/07 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 21-62 |
| NCAAF | 2023/09/30 17:30 | Hanover v Defiance Yellow Jackets | W | 21-27 |
| NCAAF | 2023/09/16 17:00 | Kalamazoo Hornets v Defiance Yellow Jackets | L | 42-35 |
| NCAAF | 2023/09/09 17:00 | Adrian Bulldogs v Defiance Yellow Jackets | W | 17-34 |
| NCAAF | 2023/09/02 17:30 | Defiance Yellow Jackets v Mount Union | L | 6-45 |
| NCAAF | 2022/11/12 18:30 | Bluffton Beavers v Defiance Yellow Jackets | W | 14-17 |