[20] Kei Nishikori 5-7,4-6 Novak Djokovic [12] 2018-05-07 14:00
Stadium: Manolo Santana Stadium Round: 24 Ground: Clay
Head to Head
| ATP World Tour Finals | 2016/11/19 20:00 | Novak Djokovic v Kei Nishikori | 6-1,6-1 |
| ATP Madrid | 2016/05/07 18:20 | Novak Djokovic v Kei Nishikori | 6-3,7-6 |
| ATP Miami | 2016/04/03 17:00 | Novak Djokovic v Kei Nishikori | 6-3,6-3 |
| US Open | 2014/09/06 16:00 | Novak Djokovic v Kei Nishikori | 4-6,6-1,6-7,3-6 |
Home History
| ATP Monte Carlo | 2018/04/22 12:30 | Rafael Nadal v Kei Nishikori | 6-3,6-2 |
| ATP Monte Carlo | 2018/04/21 13:30 | Alexander Zverev v Kei Nishikori | 6-3,3-6,4-6 |
| ATP Monte Carlo | 2018/04/20 12:40 | Kei Nishikori v Marin Cilic | 6-4,6-7,6-3 |
| ATP Monte Carlo | 2018/04/19 15:30 | Andreas Seppi v Kei Nishikori | 0-6,6-2,3-6 |
| ATP Monte Carlo | 2018/04/18 09:00 | Daniil Medvedev v Kei Nishikori | 5-7,2-6 |
| ATP Monte Carlo | 2018/04/16 10:55 | Kei Nishikori v Tomas Berdych | 4-6,6-2,6-1 |
| ATP Miami | 2018/03/25 19:40 | Juan Martin Del Potro v Kei Nishikori | 6-2,6-2 |
| ATP Miami | 2018/03/23 18:40 | John Millman v Kei Nishikori | 6-7,6-4,3-6 |
Away History
| ATP Barcelona | 2018/04/25 10:50 | Martin Klizan v Novak Djokovic | 6-2,1-6,6-3 |
| ATP Monte Carlo | 2018/04/19 11:25 | Novak Djokovic v Dominic Thiem | 7-6,2-6,3-6 |
| ATP Monte Carlo | 2018/04/18 11:00 | Novak Djokovic v Borna Coric | 7-6,7-5 |
| ATP Monte Carlo | 2018/04/16 13:10 | Novak Djokovic v Dusan Lajovic | 6-0,6-1 |
| ATP Miami | 2018/03/23 19:00 | Benoit Paire v Novak Djokovic | 6-3,6-4 |
| ATP Indian Wells | 2018/03/11 19:25 | Taro Daniel v Novak Djokovic | 7-6,4-6,6-1 |
| Australian Open | 2018/01/22 08:00 | Novak Djokovic v Hyeon Chung | 6-7,5-7,6-7 |
| Australian Open | 2018/01/20 08:00 | Novak Djokovic v Albert Ramos-Vinolas | 6-2,6-3,6-3 |