| Uruguay Reserve League | 2017/10/24 18:00 | Penarol Reserves v Defensor Sporting Reserves | L | 2-3 |
| Uruguay Reserve League | 2018/05/02 13:00 | Progreso Reserves v Penarol Reserves | D | 1-1 |
| Uruguay Reserve League | 2018/04/14 18:00 | Atletico Fenix Reserves v Penarol Reserves | W | 0-1 |
| Uruguay Reserve League | 2018/03/13 12:00 | Penarol Reserves v Boston River Reserves | L | 1-3 |
| Uruguay Reserve League | 2018/02/27 12:00 | Penarol Reserves v Liverpool Montevideo Reserves | W | 1-0 |
| Uruguay Reserve League | 2018/02/06 12:00 | Racing Club de Montevideo Reserves v Penarol Reserves | L | 3-0 |
| Uruguay Reserve League | 2017/12/19 12:30 | Penarol Reserves v Juventud De Las Piedras Reserves | D | 2-2 |
| Uruguay Reserve League | 2017/12/12 13:00 | Danubio Reserves v Penarol Reserves | D | 1-1 |
| Uruguay Reserve League | 2017/12/08 19:00 | Penarol Reserves v Montevideo Wanderers Reserves | L | 0-1 |
| Uruguay Reserve League | 2018/05/02 18:00 | Defensor Sporting Reserves v Boston River Reserves | W | 3-2 |
| Uruguay Reserve League | 2018/04/17 13:00 | Defensor Sporting Reserves v Liverpool Montevideo Reserves | L | 1-2 |
| Uruguay Reserve League | 2018/04/10 19:00 | Montevideo Wanderers Reserves v Defensor Sporting Reserves | W | 0-3 |
| Uruguay Reserve League | 2018/04/01 16:30 | Defensor Sporting Reserves v Atletico River Plate Reserves | L | 1-2 |
| Uruguay Reserve League | 2018/03/17 17:00 | Defensor Sporting Reserves v Progreso Reserves | D | 1-1 |
| Uruguay Reserve League | 2018/03/13 13:00 | Nacional de Montevideo Reserves v Defensor Sporting Reserves | D | 2-2 |
| Uruguay Reserve League | 2018/03/04 20:00 | Defensor Sporting Reserves v Atletico Fenix Reserves | L | 0-1 |
| Uruguay Reserve League | 2018/02/24 17:30 | Rampla Juniors Reserves v Defensor Sporting Reserves | W | 1-5 |