Head to Head
| Laver Cup | 2019/09/22 14:45 | Roger Federer v John Isner | 6-4,7-6 |
| ATP Miami | 2019/03/31 17:00 | John Isner v Roger Federer | 1-6,4-6 |
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |
Home History
| Others | 2023/07/23 10:00 | Roger Federer v Tim Henman | 4-6,7-6,0-1 |
| Tie Break Tens Dubai | 2021/10/21 11:37 | Andy Murray v Roger Federer | 0-0 |
| Wimbledon | 2021/07/07 15:15 | Roger Federer v Hubert Hurkacz | 3-6,6-7,0-6 |
| Wimbledon | 2021/07/05 16:30 | Roger Federer v Lorenzo Sonego | 7-5,6-4,6-2 |
| Wimbledon | 2021/07/03 14:10 | Roger Federer v Cameron Norrie | 6-4,6-4,5-7,6-4 |
| Wimbledon | 2021/07/01 16:05 | Roger Federer v Richard Gasquet | 7-6,6-1,6-4 |
| ATP Halle | 2021/06/16 12:50 | Felix Auger Aliassime v Roger Federer | 4-6,6-3,6-2 |
| ATP Halle | 2021/06/14 12:40 | Ilya Ivashka v Roger Federer | 6-7,5-7 |
Away History
| US Open | 2023/08/31 15:00 | Michael Mmoh v John Isner | 3-6,4-6,7-6,6-4,7-6 |
| US Open | 2023/08/29 19:15 | Facundo Diaz Acosta v John Isner | 4-6,3-6,6-7 |
| ATP Cincinnati | 2023/08/14 20:25 | John Isner v Jordan Thompson | 6-7,6-7 |
| ATP Los Cabos | 2023/08/03 06:45 | Stefanos Tsitsipas v John Isner | 6-2,6-4 |
| ATP Los Cabos | 2023/08/01 02:35 | Rinky Hijikata v John Isner | 2-6,6-7 |
| ATP Atlanta | 2023/07/25 19:35 | John Isner v Dominik Koepfer | 6-3,6-7,6-7 |
| ATP Newport | 2023/07/22 19:20 | John Isner v Alex Michelsen | 6-7,4-6 |
| ATP Newport | 2023/07/21 18:25 | Tommy Paul v John Isner | 6-4,3-6,6-7 |