BUF Sabres 1-5 PIT Penguins 2018-09-26 23:00
Stadium: PPG Paints Arena Round: 1
Home Manager: Mike Sullivan Away Manager: Phil Housley
Head to Head
| NHL Pre-Season | 2018/09/18 23:00 | PIT Penguins v BUF Sabres | W | 2-3 |
| NHL | 2017/12/03 00:00 | BUF Sabres v PIT Penguins | L | 1-5 |
| NHL | 2017/12/02 00:00 | PIT Penguins v BUF Sabres | L | 4-0 |
| NHL | 2017/11/15 00:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2017/09/27 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2017/09/19 23:00 | PIT Penguins v BUF Sabres | W | 3-4 |
| NHL | 2017/03/21 23:00 | PIT Penguins v BUF Sabres | L | 3-1 |
| NHL | 2017/03/05 22:00 | BUF Sabres v PIT Penguins | L | 3-4 |
Home History
| NHL Pre-Season | 2018/09/25 23:00 | CLB Blue Jackets v BUF Sabres | L | 4-2 |
| NHL Pre-Season | 2018/09/22 23:00 | TOR Maple Leafs v BUF Sabres | L | 3-2 |
| NHL Pre-Season | 2018/09/21 23:30 | BUF Sabres v TOR Maple Leafs | L | 3-5 |
| NHL Pre-Season | 2018/09/18 23:00 | PIT Penguins v BUF Sabres | W | 2-3 |
| NHL Pre-Season | 2018/09/17 23:00 | BUF Sabres v CLB Blue Jackets | W | 4-1 |
| NHL | 2018/04/07 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2018/04/06 23:30 | BUF Sabres v TB Lightning | L | 5-7 |
| NHL | 2018/04/04 23:30 | OTT Senators v BUF Sabres | L | 4-2 |
Away History
| NHL Pre-Season | 2018/09/23 19:00 | DET Red Wings v PIT Penguins | L | 3-2 |
| NHL Pre-Season | 2018/09/22 19:00 | CLB Blue Jackets v PIT Penguins | W | 3-7 |
| NHL Pre-Season | 2018/09/19 23:30 | PIT Penguins v DET Red Wings | L | 2-3 |
| NHL Pre-Season | 2018/09/18 23:00 | PIT Penguins v BUF Sabres | L | 2-3 |
| NHL | 2018/05/07 23:00 | WAS Capitals v PIT Penguins | L | 2-1 |
| NHL | 2018/05/05 23:00 | PIT Penguins v WAS Capitals | L | 3-6 |
| NHL | 2018/05/03 23:00 | WAS Capitals v PIT Penguins | W | 1-3 |
| NHL | 2018/05/01 23:30 | WAS Capitals v PIT Penguins | L | 4-3 |