Head to Head
| NFL Preseason | 2022/08/26 23:00 | BUF Bills v CAR Panthers | W | 0-21 |
| NFL | 2021/12/19 18:00 | CAR Panthers v BUF Bills | L | 14-31 |
| NFL Preseason | 2019/08/16 23:00 | BUF Bills v CAR Panthers | L | 27-14 |
| NFL Preseason | 2018/08/09 23:00 | CAR Panthers v BUF Bills | W | 28-23 |
| NFL | 2018/02/02 09:34 | BUF Bills v CAR Panthers | W | 19-25 |
| NFL | 2017/09/17 17:00 | BUF Bills v CAR Panthers | W | 3-9 |
Home History
| NFL Preseason | 2024/08/17 23:00 | NY Jets v CAR Panthers | L | 15-12 |
| NFL Preseason | 2024/08/08 23:00 | CAR Panthers v NE Patriots | L | 3-17 |
| NFL | 2024/01/07 18:00 | TB Buccaneers v CAR Panthers | L | 9-0 |
| NFL | 2023/12/31 18:00 | CAR Panthers v JAX Jaguars | L | 0-26 |
| NFL | 2023/12/24 18:00 | GB Packers v CAR Panthers | L | 33-30 |
| NFL | 2023/12/17 18:00 | ATL Falcons v CAR Panthers | W | 7-9 |
| NFL | 2023/12/10 18:00 | CAR Panthers v NO Saints | L | 6-28 |
| NFL | 2023/12/03 21:05 | CAR Panthers v TB Buccaneers | L | 18-21 |
Away History
| NFL Preseason | 2024/08/17 23:00 | BUF Bills v PIT Steelers | W | 9-3 |
| NFL Preseason | 2024/08/10 17:00 | CHI Bears v BUF Bills | L | 33-6 |
| NFL | 2024/01/21 23:30 | KC Chiefs v BUF Bills | L | 27-24 |
| NFL | 2024/01/15 21:30 | PIT Steelers v BUF Bills | W | 17-31 |
| NFL | 2024/01/08 01:20 | BUF Bills v MIA Dolphins | W | 21-14 |
| NFL | 2023/12/31 18:00 | NE Patriots v BUF Bills | W | 21-27 |
| NFL | 2023/12/24 01:00 | BUF Bills v LA Chargers | W | 24-22 |
| NFL | 2023/12/17 21:25 | DAL Cowboys v BUF Bills | W | 10-31 |