Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Bubba McDowell Away Manager: Clarence McKinney
| NCAAF | 2023/09/03 00:00 | Prairie View v Texas Southern Tigers | L | 37-34 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | L | 23-40 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | L | 40-17 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | L | 19-20 |
| NCAAF | 2019/08/31 22:30 | Prairie View v Texas Southern Tigers | L | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern Tigers v Prairie View | L | 14-60 |
| NCAAF | 2017/11/26 00:00 | Texas Southern Tigers v Prairie View | L | 16-30 |
| NCAAF | 2023/11/18 20:00 | Arkansas Pine Bluff v Texas Southern Tigers | L | 35-34 |
| NCAAF | 2023/11/12 20:00 | Alcorn State v Texas Southern Tigers | W | 10-44 |
| NCAAF | 2023/11/04 19:00 | Texas Southern Tigers v Jackson State | L | 19-21 |
| NCAAF | 2023/10/28 21:00 | Texas Southern Tigers v Southern | L | 17-23 |
| NCAAF | 2023/10/22 00:00 | Florida A&M v Texas Southern Tigers | L | 31-21 |
| NCAAF | 2023/10/14 19:00 | Texas Southern Tigers v Bethune Cookman | W | 34-31 |
| NCAAF | 2023/09/30 19:00 | Texas Southern Tigers v Lincoln Oaklanders | W | 52-7 |
| NCAAF | 2023/09/23 19:00 | Texas Southern Tigers v Grambling State | L | 23-35 |
| NCAAF | 2023/12/02 21:00 | Prairie View v Florida A&M | L | 14-35 |
| NCAAF | 2023/11/18 20:00 | Alabama State v Prairie View | W | 14-21 |
| NCAAF | 2023/11/11 20:00 | Prairie View v Southern | W | 27-21 |
| NCAAF | 2023/11/04 19:00 | Arkansas Pine Bluff v Prairie View | W | 14-38 |
| NCAAF | 2023/10/28 20:00 | Prairie View v Florida A&M | L | 7-45 |
| NCAAF | 2023/10/14 23:00 | Prairie View v Houston Christian | L | 0-30 |
| NCAAF | 2023/10/07 23:00 | Mississippi Valley State v Prairie View | W | 12-31 |
| NCAAF | 2023/09/30 23:00 | Grambling State v Prairie View | L | 35-20 |