Head to Head
| England Premier League 2 | 2023/01/27 13:00 | Middlesbrough U21 v Southampton U21 | D | 2-2 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | L | 8-1 |
Home History
| England National League Cup | 2025/01/21 19:30 | Boston Utd v Middlesbrough U21 | L | 6-5 |
| England Premier League 2 | 2025/01/17 19:00 | Blackburn U21 v Middlesbrough U21 | L | 3-2 |
| Premier League International Cup | 2025/01/14 19:00 | Middlesbrough U21 v Athletic Bilbao U21 | L | 0-4 |
| Premier League International Cup | 2024/12/18 19:00 | Middlesbrough U21 v Benfica U21 | L | 0-1 |
| England Premier League 2 | 2024/12/13 19:00 | Norwich U21 v Middlesbrough U21 | W | 1-3 |
| England Premier League 2 | 2024/11/29 12:00 | Tottenham U21 v Middlesbrough U21 | L | 6-1 |
| England National League Cup | 2024/11/12 19:00 | Halifax v Middlesbrough U21 | W | 1-4 |
| Premier League International Cup | 2024/11/06 19:00 | Middlesbrough U21 v Borussia M'gladbach U21 | W | 3-2 |
Away History
| England Premier League 2 | 2025/01/24 19:00 | Chelsea U21 v Southampton U21 | W | 0-2 |
| Premier League International Cup | 2025/01/21 19:00 | Southampton U21 v Anderlecht Reserves | W | 3-1 |
| England Premier League 2 | 2025/01/17 12:00 | Southampton U21 v Newcastle U21 | W | 4-2 |
| England Premier League 2 | 2025/01/10 19:00 | Southampton U21 v Fulham U21 | W | 5-0 |
| Premier League International Cup | 2024/12/19 19:00 | Southampton U21 v Sporting U21 | L | 0-5 |
| England Premier League 2 | 2024/12/14 12:00 | Man Utd U21 v Southampton U21 | L | 5-1 |
| Premier League International Cup | 2024/12/10 19:00 | Southampton U21 v Real Sociedad U21 | L | 3-4 |
| England National League Cup | 2024/12/03 19:00 | Aldershot v Southampton U21 | L | 2-1 |